I found this study very interesting. My son was diagnosed early on with a s
An excerpt from the press release:
The most significant obstacle to developing an animal model of food allergy is that animals are not normally allergic to food. Scientists must add a strong immune stimulant to foods to elicit a reaction in animals that resembles food allergy in humans. Because of this requirement, useful animal models have been developed only in the last few years, and such animal models have until now used cholera toxin as the immune stimulant.
Dr. Bryce’s team took the novel approach of feeding mice a mixture of whole peanut extract (WPE) and a toxin from the bacteria Staphylococcus aureus, called staphylococcal enterotoxin B (SEB) to simulate the human anaphylactic reaction to peanuts in mice.
“Persistent S. aureus colonization is commonly found on the skin of people with eczema and in the nasal cavities of people with sinusitis,” says Dr. Bryce. “The history between S. aureus and allergic diseases led us to use staphylococcal toxins to stimulate food allergy in animals.”
According to Dr. Bryce, the results using the SEB/WPE mixture were considerably better than those seen with previous animal models, which failed to mimic many features of food allergy. They showed that the SEB/WPE mixture stimulated severe symptoms in mice that closely resemble those found in human anaphylaxis, including swelling around the eyes and mouth, reduced movement and significant problems breathing. Additionally, mice given the SEB/WPE mixture had high blood levels of histamine, which indicates a severe allergic reaction.
Read the entire press release here: